臺灣深層海水資源利用學會 TAIWAN SOCIETY OF DEEP OCEAN WATER RESOURCE APPLICATION
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以深層海水培養牛樟芝之代謝產物能有效防止硫乙醯胺誘導肝臟纖維化

8/3/2015

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Antrodia camphorata-fermented product cultured in deep ocean water has more liver protection against thioacetamide-induced fibrosis.

Wang LC(1), Kuo IU, Tsai TY, Lee CL.
Author information:
(1)Continuing Education School, National Taitung Junior College, Taitung, Taiwan, Republic of China.

Antrodia camphorata is a unique fungus in Taiwan; the submerged fermentation product is used as the functional food for liver protection. Deep ocean water (DOW) containing rich metals and trace elements is proven to stimulate the production of functional metabolites and health function of functional fungus product in our previous study. Therefore, A. camphorata-fermented product cultured in DOW (DOW-AC) or reverse osmosis water (ROW-AC) as culture water was daily fed thioacetamide (TAA)-induced fibrosis rat for 8 weeks in order to investigate whether DOW promoted the effect of A. camphorata-fermented product on

the prevention against TAA-induced liver damage and fibrosis. In the results, feeding one dose of DOW-AC prevented from TAA-induced weight loss and had more effect on inhibiting lipid peroxidation, reactive oxygen species, iNOS, and TNF-α expression than one dose of ROW-AC. Furthermore, DOW-AC also had more potent effect on protection against TAA-induced liver damage and fibrosis according to the results of H&E stain and collagen stain. However, higher liver protection of DOW-AC should be due to the fact that DOW not only increased the production of A. camphorata-fermented functional metabolites including triterpenoids,

polysaccharides, flavonoids, and polyphenols but also contributed to protection against TAA-induced damage and fibrosis.

PMID: 24061418  [PubMed - indexed for MEDLINE]
資料來源-http://www.ncbi.nlm.nih.gov/pubmed/24061418

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種々のカルシウム/マグネシウム比で培養した ヒト線維芽細胞の活性と海洋深層水添加効果

8/3/2015

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Cell viability of human broblasts cultured with various ratios of calcium and magnesium and eects of deep seawater supplementation

山田勝久1 ・鈴木正宏1 ・野村道康1 ・柴田雄次2 ・今田千秋2 Katsuhisa YAMADA1 , Masahiro SUZUKI1 , Michiyasu NOMURA1 , Yuji SHIBATA2 and Chiaki IMADA2

要  旨

カルシウム/マグネシウム摂取比(以後,Ca/Mg比)の増大は虚血性心疾患のリスクを生じさせることは周知のとおりである.また動物実験によるCa/Mg比の増大と虚血性心疾患についての報告はあるが,Ca/Mg比に関する細胞レベルの研究報告はほとんど見当たらない.そこで継代数が異なる培養線維芽細胞を用いて,CaおよびMgのさまざまな割合の影響を調査した.その結果,継代数が14回の細胞(老化したと考えられる細胞)ではCa/Mg比が高い条件で培養すると細胞活性が顕著に低下した.この現象は本研究で使用された範囲内でのCa濃度の増加にかかわりなくCa/Mg比に依存することが示唆された.しかし,Ca/Mg比の増大に伴って細胞活性が低下する条件において,Ca/Mg比を変えない量の伊豆赤沢産の海洋深層水(以後,DSW)を添加して培養した結果,細胞活性の低下が阻止されることが示唆された.本研究の結果から,食の多様化に伴ってCa/Mg比が増加傾向にある日本の食事に対してDSWの利用は健康維持上有用な一つのアプローチになると思われる.

完整資訊:http://www.etdic.org.tw/Uploader/files/1040722.pdf

資料來源-DOWAS
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