臺灣深層海水資源利用學會 TAIWAN SOCIETY OF DEEP OCEAN WATER RESOURCE APPLICATION
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以深層海水培養牛樟芝之代謝產物能有效防止硫乙醯胺誘導肝臟纖維化

8/3/2015

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Antrodia camphorata-fermented product cultured in deep ocean water has more liver protection against thioacetamide-induced fibrosis.

Wang LC(1), Kuo IU, Tsai TY, Lee CL.
Author information:
(1)Continuing Education School, National Taitung Junior College, Taitung, Taiwan, Republic of China.

Antrodia camphorata is a unique fungus in Taiwan; the submerged fermentation product is used as the functional food for liver protection. Deep ocean water (DOW) containing rich metals and trace elements is proven to stimulate the production of functional metabolites and health function of functional fungus product in our previous study. Therefore, A. camphorata-fermented product cultured in DOW (DOW-AC) or reverse osmosis water (ROW-AC) as culture water was daily fed thioacetamide (TAA)-induced fibrosis rat for 8 weeks in order to investigate whether DOW promoted the effect of A. camphorata-fermented product on

the prevention against TAA-induced liver damage and fibrosis. In the results, feeding one dose of DOW-AC prevented from TAA-induced weight loss and had more effect on inhibiting lipid peroxidation, reactive oxygen species, iNOS, and TNF-α expression than one dose of ROW-AC. Furthermore, DOW-AC also had more potent effect on protection against TAA-induced liver damage and fibrosis according to the results of H&E stain and collagen stain. However, higher liver protection of DOW-AC should be due to the fact that DOW not only increased the production of A. camphorata-fermented functional metabolites including triterpenoids,

polysaccharides, flavonoids, and polyphenols but also contributed to protection against TAA-induced damage and fibrosis.

PMID: 24061418  [PubMed - indexed for MEDLINE]
資料來源-http://www.ncbi.nlm.nih.gov/pubmed/24061418

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